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Chemoprophylaxis with tenofovir disoproxil fumarate provided partial protection against infection with simian human immunodeficiency virus in macaques given multiple virus challenges.
J Infect Dis. 2006 Oct 1;194(7):904-11. doi: 10.1086/507306. Epub 2006 Aug 29.
J Infect Dis. 2006.
PMID: 16960777
We examined the efficacy of tenofovir disoproxil fumarate (TDF) in blocking simian human immunodeficiency virus (SHIV) infection in Chinese rhesus macaques. Once weekly for 14 weeks or until a macaque became infected, 12 male macaques were inoculated intrarectally w …
We examined the efficacy of tenofovir disoproxil fumarate (TDF) in blocking simian human immunodeficiency virus (SHIV) infecti …
Repetitive exposures with simian/human immunodeficiency viruses: strategy to study HIV pre-clinical interventions in non-human primates.
Kim CN, Adams DR, Bashirian S, Butera S, Folks TM, Otten RA.
Kim CN, et al.
J Med Primatol. 2006 Aug;35(4-5):210-6. doi: 10.1111/j.1600-0684.2006.00169.x.
J Med Primatol. 2006.
PMID: 16872284
BACKGROUND: Non-human primate models for human immunodeficiency virus (HIV) infection represent a valuable pre-clinical tool to evaluate interventions (e.g., topical microbicides, vaccines, and chemoprophylaxis) designed to prevent transmission or slow disease progression …
BACKGROUND: Non-human primate models for human immunodeficiency virus (HIV) infection represent a valuable pre-clinical tool to evalu …
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